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PIK-90
Cat. No.:
OB0225WX-1553
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
PIK-90 acts as a multi-kinase inhibitor that targets DNA-PK and various PI3K subunits, with IC50 values of 13 nM (DNA-PK), 11 nM (p110α), and 18 nM (p110γ).
Synonym:
677338-12-4; PIK90; N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide; N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyridine-3-carboxamide; N-(7,8-Dimethoxy-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl)nicotinamide; N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)nicotinamide; N-{7,8-dimethoxy-2H,3H-imidazo[1,2-c]quinazolin-5-yl}pyridine-3-carboxamide; N-(7,8-dimethoxy-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene)pyridine-3-carboxamide; PIK 90; PI 3-K inhibitor IX; N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide; N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide; N-{7,8-dimethoxy-1H,2H,3H-imidazo[1,2-c]quinazolin-5-ylidene}pyridine-3-carboxamide
CAS No.:
677338-12-4
Compound CID:
135398491
Formula:
C18H17N5O3
Formula Weight:
351.36
Specification
Targets&IC50:
PI3Kγ: 18 nM; PI3Kα: 11 nM; DNA-PK: 13 nM
Relative Density:
1.42 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PIK-90 is employed in signaling transduction research to study the concurrent inhibition of multiple PI3K isoforms and their effect on the downstream AKT/mTOR pathway.
Library Information
Target:
DNA-PK; PI3K
Receptor:
DNA-PK; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Pathways:
DNA damage/DNA repair; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-20
Plate Location:
h8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
<0.2 mg/mL; insoluble or slightly soluble)
Water Max Solubility:
<0.2 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<0.2 mg/mL (insoluble or slightly soluble)
