AZ6102

Cat. No.: OB0225WX-1706

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

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Product Overview

Description: AZ6102 is a potent TNKS1/2 inhibitor exhibiting 100-fold selectivity over other enzymes in the PARP family and a measured IC50 of 5 nM for Wnt pathway suppression in DLD-1 cells.

Synonym: 1645286-75-4; AZ-6102; AZ 6102; 2-(4-(6-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one; 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-, rel-; 2-(4-(6-(cis-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one; 2-[4-[6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4-one; 2-(4-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-7-methyl-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one; 2-(4-(6-((3S,5R)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3Hpyrrolo[2,3-d]pyrimidin-4(7H)-one

CAS No.: 1645286-75-4

Compound CID: 135905416

Formula: C₂₅H₂₈N₆

Formula Weight: 428.53

Specification

Targets&IC50: TNKS2: 5 nM; TNKS1: 5 nM

Relative Density: 1.31 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: AZ6102 is utilized in biochemical assays as a dual inhibitor of tankyrase 1 and 2 to investigate the molecular mechanisms of axin stabilization in various neoplastic cell lines.