KU60019

Cat. No.: OB0225WX-2341

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, ORP, CSFC, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Ku-60019 acts as a powerful and reversible antagonist of ATM kinase, featuring an IC50 of 6.3 nM and exhibiting exceptional selectivity when screened against a panel of 229 other kinases.

Synonym: KU-60019; KU 60019; 925701-49-1; ku60019; 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide; 4-Morpholineacetamide, 2,6-dimethyl-N-(5-(6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)-, (2R,6S)-; (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide; 2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide; 2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide.; 2-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]-N-{5-[6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl}acetamide; 2-((2S,6R)-2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl)acetamide; rel-(2R,6S)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide

CAS No.: 925701-49-1

Compound CID: 15953870

Formula: C₃₀H₃₃N₃O₅S

Formula Weight: 547.67

Specification

Targets&IC50: ATM: 6.3 nM (cell free)

Relative Density: 1.314 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: KU60019 is used in signal transduction research to investigate the role of ATM-mediated phosphorylation in cellular senescence and the maintenance of genomic integrity following oxidative damage.