GNE-3511

Cat. No.: OB0225WX-1749

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: GNE-3511 is a specialized small molecule characterized by its high potency and selectivity as a dual leucine zipper kinase (DLK) inhibitor.

Synonym: GNE3511; 1496581-76-0; 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile; GNE 3511; 2-[[6-[3,3-Bis(Fluoranyl)pyrrolidin-1-Yl]-4-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyridin-2-Yl]amino]pyridine-4-Carbonitrile; 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile; 2-[[6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-4-pyridinecarbonitrile; 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)pyridine-4-carbonitrile; 2-(6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-ylamino)isonicotinonitrile; 50D

CAS No.: 1496581-76-0

Compound CID: 72547959

Formula: C₂₃H₂₆F₂N₆O

Formula Weight: 440.49

Specification

Targets&IC50: DLK: 0.5 nM. (Ki)

Relative Density: 1.37 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: GNE-3511 is employed in neurodegeneration research as a highly selective and brain-penetrant DLK inhibitor to investigate the protection of axons and the mitigation of neuronal cell death.