Products
Online Inquiry
NU 7026
Cat. No.:
OB0225WX-1551
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
NU 7026 is a potent DNA-PK inhibitor with an IC50 of 0.23 μM in cell-free environments, showing 60-fold greater selectivity over PI3K and no detectable activity against ATR or ATM.
Synonym:
NU7026; DNA-PK Inhibitor II; 154447-35-5; NU 7026; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one; NU-7026; 2-morpholino-4H-benzo[h]chromen-4-one; 2-morpholin-4-ylbenzo[h]chromen-4-one; LY-293646; 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one; LY293646; 2-(morpholin-4-yl)benzo[h]chromen-4-one; MFCD06798345; 2-(morpholin-4-yl)benzo(h)chromen-4-one; 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
CAS No.:
154447-35-5
Compound CID:
9860529
Formula:
C17H15NO3
Formula Weight:
281.31
Specification
Targets&IC50:
DNA-PK: 0.23 μM
Relative Density:
1.330 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
NU 7026 is utilized in DNA repair research as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) to study cellular sensitivity to ionizing radiation and chemotherapeutic agents.
Library Information
Target:
ATM/ATR; DNA-PK; PI3K
Receptor:
ATM; ATR; DNA-PK; PI3K
Pathways:
DNA damage/DNA repair; PI3K/Akt/mTOR signaling; Apoptosis
Plate Number:
AOCL-20
Plate Location:
h6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
2mM DMSO
DMSO Max Solubility:
2.8 mg/mL; 10 mM
