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Thiomyristoyl
Cat. No.:
OB0225WX-2740
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Thiomyristoyl is a highly specific SIRT2 inhibitor (IC50: 28 nM) that exhibits minimal activity against SIRT1 (IC50: 98 micromolar) and no detectable inhibition of SIRT3.
Synonym:
TM; 1429749-41-6; Benzyl N-[(2S)-1-anilino-1-oxo-6-(tetradecanethioylamino)hexan-2-yl]carbamate; N-[(1S)-1-[(Phenylamino)carbonyl]-5-[(1-thioxotetradecyl)amino]pentyl]-carbamicAcidPhenylmethylEster; Benzyl (S)-(1-oxo-1-(phenylamino)-6-tetradecanethioamidohexan-2-yl)carbamate; TMFCD30738003; Benzyl N-[(1S)-1-(phenylcarbamoyl)-5-tetradecanethioamidopentyl]carbamate
CAS No.:
1429749-41-6
Compound CID:
126843233
Formula:
C34H51N3O3S
Formula Weight:
581.85
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Thiomyristoyl is applied in epigenetic research as a potent and selective SIRT2 inhibitor to investigate the modulation of lysine demyristoylation and its subsequent impact on specific protein targets and cellular stress responses.
Library Information
Target:
Sirtuin
Receptor:
SIRT1; SIRT2
Pathways:
DNA damage/DNA repair
Plate Number:
L6700-10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 171.87 mM
Ethanol Max Solubility:
100 mg/mL
ALogP:
9.441
HBA_Count:
3
HBD_Count:
3
Rotatable Bond:
24
