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VE-821
Cat. No.:
OB0225WX-2349
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR.
Size:
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Product Overview
Description:
VE-821 is a selective, ATP-competitive inhibitor of ATR with an inhibition constant (Ki) of 13 nM and an IC50 of 26 nM in cell-free assays.
Synonym:
ATR Inhibitor IV; 1232410-49-9; 3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide; VE 821; VE821; 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide; 3-Amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide; 2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-; 2-Pyrazinecarboxamide, 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenyl-; 3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide; 3-Azanyl-6-(4-methylsulfonylphenyl)-N-phenyl-pyrazine-2-carboxamide; VE821 cpd; MFCD19443686; 3-Amino-6-[4-(methanesulfonyl)phenyl]-N-phenylpyrazine-2-carboxamide
CAS No.:
1232410-49-9
Compound CID:
51000408
Formula:
C18H16N4O3S
Formula Weight:
368.41
Specification
Targets&IC50:
ATR: 13 nM (Ki; cell free)
Relative Density:
1.394 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
VE-821 is used in molecular pharmacology as a selective ATR inhibitor to investigate the molecular basis of ATR-dependent survival in cells under chronic replication stress.
Library Information
Target:
ATM/ATR
Receptor:
ATR
Pathways:
DNA damage/DNA repair; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-31
Plate Location:
a11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
69 mg/mL; 187.3 mM
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
