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ETP-46464
Cat. No.:
0225LY-0594
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
ETP-46464 serves as a specialized and effective inhibitor of ATR, characterized by an IC50 of 25 nM.
Synonym:
1345675-02-6; ETP46464; 2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)propanenitrile; 2-Methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile; Alpha,alpha-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile; 2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile
CAS No.:
1345675-02-6
Compound CID:
72199292
Formula:
C30H22N4O2
Formula Weight:
470.52
Specification
Targets&IC50:
ATR: 25nM
Relative Density:
1.310 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ETP-46464 can be used in DNA damage response research to investigate its role as a potent and selective ATR kinase inhibitor.
Library Information
Target:
ATM/ATR; PI3K; DNA-PK; mTOR
Receptor:
ATM/ATR; DNA-PK; mTOR; PI3Kα
Pathways:
PI3K/Akt/mTOR signaling; DNA damage/DNA repair
Plate Number:
AOCL-8
Plate Location:
f9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
6 mg/mL; 12.75 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL
ALogP:
5.813
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
3
