PD168393

Cat. No.: OB0225WX-2663

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: PD168393 functions as an irreversible antagonist of EGFR (IC50: 0.70 nM) by covalently alkylating the Cys-773 residue, while remaining inactive against PKC, FGFR, PDGFR, and insulin receptors.

Synonym: 194423-15-9; PD-168393; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; pd 168393; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide; n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide; N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide; 2-Propenamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-; nchembio866-comp2; N-[4-[(3-bromophenyl)amino]quinazolin-6-yl]acrylamide; 4-anilinoquinazoline deriv. 2; N-(4-(3-Bromophenylamino)quinazolin-6-yl)acrylamide; N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide;4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline

CAS No.: 194423-15-9

Compound CID: 4708

Formula: C₁₇H₁₃BrN₄

Formula Weight: 369.22

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: PD168393 is utilized in oncology research as a potent and irreversible inhibitor of the EGFR tyrosine kinase to study the suppression of aberrant growth signaling in various solid tumor models.