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Cediranib maleate
Cat. No.:
OB0225WX-2617
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Cediranib maleate is the maleate salt of a high-potency pan-VEGFR inhibitor, exhibiting IC50 values of less than 1 nM against VEGFR and sub-5 nM against Flt1/4.
Synonym:
AZD-2171 maleate; 857036-77-2; Cediranib (maleate); AZD-2171 maleate; Cediranib maleat; (Z)-but-2-enedioic acid;4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline; 4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline maleate; Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-, (2Z)-2-butenedioate (1:1); 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (2Z)-but-2-enedioate; 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline maleate
CAS No.:
857036-77-2
Compound CID:
11226834
Formula:
C25H27FN4O3·C4H4O4
Formula Weight:
566.58
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Cediranib maleate is employed in oncology research as a potent pan-VEGFR inhibitor to investigate the disruption of tumor vascularization and the inhibition of growth factor-mediated signaling.
Library Information
Target:
VEGFR
Receptor:
VEGFR
Pathways:
Protein tyrosine kinase
Plate Number:
L6700-06
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 176.5 mM
ALogP:
1.765
HBA_Count:
7
HBD_Count:
1
Rotatable Bond:
10
