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CCG215022
Cat. No.:
0225LY-1353
Purity:
≥99%
Identity:
Confirmed by NMR.
Size:
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Product Overview
Description:
CCG215022 acts as an inhibitor of G protein-coupled receptor kinases (GRKs), displaying IC50 values of 0.15 uM for GRK2, 0.38 uM for GRK5, and 3.9 uM for GRK1.
Synonym:
1813527-81-9; 4-(4-fluoro-3-((pyridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; CCG-215022; 4-[4-fluoro-3-(pyridin-2-ylmethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide; 4-(4-fluoro-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; 4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(2H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS No.:
1813527-81-9
Compound CID:
118888941
Formula:
C26H22FN7O3
Formula Weight:
499.5
Specification
Targets&IC50:
GRK1: 3.9±1 μM; GRK5: 0.38±0.06 μM; GRK2: 0.15±0.07 μM
Relative Density:
1.422 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
CCG215022 can be used in molecular research to explore the inhibition of the Rho-GTPase signaling pathway.
Library Information
Target:
GRK; PKA
Receptor:
GRK1; GRK2; GRK5; PKA
Pathways:
Tyrosine kinase/adaptors; GPCR/G protein signaling
Plate Number:
AOCL-18
Plate Location:
d3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
150 mg/mL; 300.3 mM
