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GLPG0634 analog
Cat. No.:
0225LY-1362
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
GLPG0634 analog acts as a specific JAK1 inhibitor, showing IC50 values of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Synonym:
GLPG0634 analogue; 1206101-20-3; Filgotinib; GLPG0634; GLPG-0634; N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; Filgotinib (GLPG0634); N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide; Filgotinib(GLPG0634); N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide; G146034; G-146034; N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide.; N-(5-{4-[(1,1-Dioxidothiomorpholin-4-Yl)methyl]phenyl}[1,2,4]triazolo[1,5-A]pyridin-2-Yl)cyclopropanecarboxamide
CAS No.:
1206101-20-3
Compound CID:
49831257
Formula:
C23H18N6O2
Formula Weight:
410.43
Specification
Targets&IC50:
JAK3: 810nM; TYK2: 116 nM; JAK1: 10nM; JAK2: 28nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GLPG0634 analog can be used in drug discovery research to explore the structure-activity relationship of selective JAK1 inhibitors.
Library Information
Target:
Tyrosine kinases; JAK
Receptor:
JAK1; JAK2; JAK3; TYK2
Pathways:
JAK/STAT signaling; Stem cell regulation; Angiogenesis; Tyrosine kinase/adaptors; Chromatin/Epigenetic
Plate Number:
AOCL-18
Plate Location:
e2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
7.5 mg/mL; 18.27 mM
ALogP:
3.695
HBA_Count:
5
HBD_Count:
1
Rotatable Bond:
6
