Decernotinib

Cat. No.: 0225LY-1355

Purity: ≥99%

Identity: Confirmed by NMR.

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Product Overview

Description: Decernotinib is identified as a selective and potent Janus kinase 3 (JAK3) inhibitor, possessing a Ki of 2.5 nM and an IC50 range of 50-170 nM in cellular environments.

Synonym: VX-509; VRT-831509; 944842-54-0; Adelatinib; Decernotinib (VX-509); VRT-831509; Decernotinib(VX-509); VX509; (R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide; Decernotinib (VX-509,adelatinib); VX 509; (2R)-2-Methyl-2-((2-(1H-pyrrolo(2,3-b)pyridin-3-yl)pyrimidin- 4-yl)amino)-N-(2,2,2-trifluoroethyl)butanamide; (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-(2,2,2-trifluoroethyl)butanamide; Butanamide, 2-methyl-2-((2-(1H-pyrrolo(2,3-b)pyridin-3-yl)-4-pyrimidinyl)amino)-N-(2,2,2-trifluoroethyl)-, (2R)-; (2r)-2-Methyl-2-[[2-(1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-4-Yl]amino]-N-[2,2,2-Tris(Fluoranyl)ethyl]butanamide; (R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide

CAS No.: 944842-54-0

Compound CID: 59422203

Formula: C₁₈H₁₉F₃N₆

Formula Weight: 392.38

Specification

Targets&IC50: JAK3: 2.5 nM(Ki)

Relative Density: 1.363 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Decernotinib can be used in immunology research to investigate the selective inhibition of JAK3 in the treatment of autoimmune disorders.