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S3I-201
Cat. No.:
OB0225WX-2397
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
S3I-201 is a potent inhibitor of STAT3 DNA-binding activity (IC50: 86 microM) characterized by its low cross-reactivity with STAT1 and STAT5.
Synonym:
NSC 74859; 501919-59-1; Nsc 74859; 2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid; S31-201; 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid; Benzoic acid, 2-hydroxy-4-((2-(((4-methylphenyl)sulfonyl)oxy)acetyl)amino)-; 2-hydroxy-4-{2-[(4-methylbenzenesulfonyl)oxy]acetamido}benzoic acid; S2I-201; Stat3 Inhibitor VI, S3I-201; 2-Hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid; 2-Hydroxy-4-((((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid; 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid; 2-Hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}acetamido)benzoic acid; 2-hydroxy-4-{2-[(4-methylbenzene-1-sulfonyl)oxy]acetamido}benzoic acid
CAS No.:
501919-59-1
Compound CID:
252682
Formula:
C16H15NO7S
Formula Weight:
365.36
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
S3I-201 is utilized in signal transduction research as a selective STAT3 inhibitor to study the disruption of STAT3 dimerization and the subsequent inhibition of STAT3-dependent gene transcription in cancer cells.
Library Information
Target:
STAT
Receptor:
STAT3
Pathways:
JAK/STAT
Plate Number:
L6700-01
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
73 mg/mL; 199.8 mM
ALogP:
1.712
HBA_Count:
3
HBD_Count:
2
Rotatable Bond:
6
