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Fedratinib
Cat. No.:
0225LY-1357
Purity:
≥99%
Identity:
Confirmed by NMR.
Size:
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Product Overview
Description:
Fedratinib is an ATP-competitive inhibitor primarily targeting JAK2 (IC50: 3 nM), showing significantly higher potency compared to its activity against JAK3.
Synonym:
TG-101348; SAR 302503; 936091-26-8; Tg-101348; TG101348; SAR302503; SAR-302503; N-(tert-butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide; Fedratinib (SAR302503, TG101348); Inrebic; SAR 302503; N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide; N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide; Benzenesulfonamide, N-(1,1-dimethylethyl)-3-((5-methyl-2-((4-(2-(1-pyrrolidinyl)ethoxy)phenyl)amino)-4-pyrimidinyl)amino)-; N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide; N-Tert-butyl-3-(5-methyl-2-(4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino)-pyrimidin-4-ylamino)-benzenesulfonamide; N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide
CAS No.:
936091-26-8
Compound CID:
16722836
Formula:
C27H36N6O3S
Formula Weight:
524.68
Specification
Targets&IC50:
JAK2: 3 nM (cell free); FLT3: 15 nM (cell free); JAK2 (V617F): 3 nM (cell free); RET: 48 nM (cell free)
Relative Density:
1.247 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Fedratinib can be used in hematology research to investigate the selective inhibition of JAK2 in myeloproliferative neoplasms.
Library Information
Target:
JAK; FLT; c-RET
Receptor:
FLT3; JAK; JAK2; JAK2 (V617F); RET
Pathways:
JAK/STAT signaling; Chromatin/Epigenetic; Stem cell regulation; Apoptosis; Angiogenesis; Tyrosine kinase/adaptors
Plate Number:
AOCL-18
Plate Location:
d7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
240 mg/mL; 457.42 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
ALogP:
5.123
HBA_Count:
5
HBD_Count:
3
Rotatable Bond:
11
