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JAK3-IN-6
Cat. No.:
0225LY-1368
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by LC-MS.
Size:
Add to basket
Product Overview
Description:
JAK3-IN-6 operates as an irreversible inhibitor of Janus kinase 3 (JAK3), boasting a high potency with an IC50 of 0.15 nM.
Synonym:
1443235-95-7; JAK3-IN-2; Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate; Ethyl 4-[3-(2-methylprop-2-enoylamino)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate; Selective JAK3 inhibitor 1; JAK3-IN-6 (Compound 2); Ethyl 4-[3-(2-methylprop-2-enamido)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate; Ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
CAS No.:
1443235-95-7
Compound CID:
89629876
Formula:
C19H18N4O3
Formula Weight:
350.37
Specification
Targets&IC50:
JAK3: 0.15 nM
Relative Density:
1.302 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
JAK3-IN-6 can be used in signaling studies to examine the selective blockade of the JAK3 kinase pathway.
Library Information
Target:
JAK3
Receptor:
JAK3
Pathways:
JAK/STAT signaling; Stem cell regulation; Angiogenesis; Chromatin/Epigenetic
Plate Number:
AOCL-18
Plate Location:
e10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 713.53 mM
ALogP:
2.959
HBA_Count:
5
HBD_Count:
2
Rotatable Bond:
6
