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ETP-45658
Cat. No.:
0225LY-0621
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
ETP-45658 inhibits PI3K isoforms alpha, delta, beta, and gamma (IC50: 22, 30, 129, and 710 nM, respectively) and also acts on DNA-PK (IC50: 70.6 nM) and mTOR (IC50: 152 nM).
Synonym:
ETP45658; ETP 45658; 1198357-79-7; 3-(1-Methyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol; 3-(1-methyl-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-6-yl)phenol; 3-(4-Morpholino-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-6-yl)phenol; 3-[1-methyl-4-(morpholin-4-yl)pyrazolo[3,4-d]pyrimidin-6-yl]phenol
CAS No.:
1198357-79-7
Compound CID:
25229608
Formula:
C16H17N5O2
Formula Weight:
311.34
Specification
Targets&IC50:
mTOR: 152.0 nM (IC50); PI3Kγ: 717.3 nM (IC50); DNA-PK: 70.6 nM (IC50); PI3Kα: 22.0 nM (IC50); PI3Kδ: 39.8 nM (IC50); PI3Kβ: 129.0 nM (IC50)
Relative Density:
1.44 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ETP-45658 can be used in metabolic signaling research to study the selective inhibition of the DNA-PK and PI3K pathways.
Library Information
Target:
DNA-PK; PI3K; mTOR
Receptor:
DNA-PK; mTOR; PI3k
Pathways:
PI3K/Akt/mTOR signaling; DNA damage/DNA repair
Plate Number:
AOCL-9
Plate Location:
a7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 192.72 mM
