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ZD-4190
Cat. No.:
OB0225WX-2659
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
ZD-4190 is a submicromolar inhibitor of VEGF receptor tyrosine kinase activity, featuring IC50 values of 29 nM and 708 nM for KDR and Flt-1, respectively.
Synonym:
413599-62-9; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine; ZD4190; 7-(2-(1H-1,2,3-Triazol-1-yl)ethoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1,2,3-triazol-1-yl)ethoxy]quinazolin-4-amine; n-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1h-1,2,3-triazol-1-yl)ethoxy]quinazolin-4-amine
CAS No.:
413599-62-9
Compound CID:
5329032
Formula:
C19H16BrFN6O2
Formula Weight:
459.27
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ZD-4190 is utilized in oncology research as an orally active inhibitor of VEGFR and EGFR signaling to study the simultaneous disruption of tumor-induced angiogenesis and growth factor-dependent proliferation.
Library Information
Target:
VEGFR
Receptor:
VEGFR
Pathways:
Protein tyrosine kinase
Plate Number:
L6700-07
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
12 mg/mL; 26.13 mM
ALogP:
4.229
HBA_Count:
6
HBD_Count:
1
Rotatable Bond:
7
