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XMD8-87
Cat. No.:
0225LY-0864
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
XMD8-87 is a TNK2 inhibitor that effectively blocks the phosphorylation of TNK2, including the truncated mutations frequently observed in various solid tumors.
Synonym:
ACK1-B19; 1234480-46-6; XMD8-87; 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-; 2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one; 2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one; 2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5Hbenzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one; 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one; Scaffold, B19; MFCD30742941
CAS No.:
1234480-46-6
Compound CID:
53322923
Formula:
C24H27N7O2
Formula Weight:
445.52
Specification
Targets&IC50:
R806Q mutations: 77 nM; D163E mutations: 16nM
Relative Density:
1.283 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
XMD8-87 can be used in signaling research to investigate the selective inhibition of the BMK1 (ERK5) pathway.
Library Information
Target:
Tyrosinase; PPAR
Receptor:
TNK2; Tyrosinase
Pathways:
DNA damage/DNA repair; Proteases/Proteasome; Metabolism
Plate Number:
AOCL-12
Plate Location:
b3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
5.33 mg/mL; 11.96 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
5 mg/mL; 11.22 mM
