azd1390

Cat. No.: OB0225WX-2348

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: AZD1390 is an exceptionally potent cellular ATM inhibitor (IC50: 0.78 nM) characterized by its 10,000-fold selectivity over other enzymes in the PIKK family.

Synonym: AZD1390; 2089288-03-7; AZD-1390; 7-fluoro-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-1-propan-2-ylimidazo[4,5-c]quinolin-2-one; Azd 1390; 7-fluoro-1-isopropyl-3-methyl-8-(6-(3-(piperidin-1-yl)propoxy)pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 2H-Imidazo(4,5-C)quinolin-2-one, 7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-(6-(3-(1-piperidinyl)propoxy)-3-pyridinyl)-; 7-Fluoro-1-isopropyl-3-methyl-8-(-(3-(1-piperidinyl)propoxy)-3-pyridinyl)-1,3-dihydro-2himidazo(4,5-C)quinolin-2-one; 7-fluoro-1-isopropyl-3-methyl-8-(6-(3-(piperidin-1-yl)propoxy)pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one; 7-fluoro-3-methyl-8-(6-(3-piperidin-1-ylpropoxy)pyridin-3-yl)-1-propan-2-ylimidazo(4,5-c)quinolin-2-one; 7-fluoro-1-isopropyl-3-methyl-8-{6-[3-(piperidin-1-yl)propoxy]pyridin-3-yl}imidazo[4,5-c]quinolin-2-one

CAS No.: 2089288-03-7

Compound CID: 126689157

Formula: C₂₇H₃₂FN₅O₂

Formula Weight: 477.57

Specification

Targets&IC50: ATM: 0.78 nM (cell based)

Relative Density: 1.224 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: azd1390 is employed in advanced neurological research as a highly potent, brain-permeable ATM inhibitor to study the sensitization of glioma cells to radiation-induced DNA damage.