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PF-AKT400
Cat. No.:
OB0225WX-1660
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
PF-AKT400 is a broadly selective, ATP-competitive small molecule that functions as a potent inhibitor of the AKT protein kinase family.
Synonym:
AKT protein kinase inhibitor; 1004990-28-6; Akt inhibitor; (S)-N-[[3-Amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl]-2,4-difluorobenzamide; N-{[(3s)-3-Amino-1-(5-Ethyl-7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)pyrrolidin-3-Yl]methyl}-2,4-Difluorobenzamide; (S)-N-[[3-Amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl]-2,4-difluorobenzamide.; N-[[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl]-2,4-difluorobenzamide; (S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-2,4-difluorobenzamide; Benzamide,N-[[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-pyrrolidinyl]methyl]-2,4-difluoro-; N-[[(3S)-3-Amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-pyrrolidinyl]methyl]-2,4-difluoro-benzamide, AldrichCPR; N-{[(3s)-3-amino-1-(5-ethyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]-methyl}-2,4-difluoro-benzamide
CAS No.:
1004990-28-6
Compound CID:
25061501
Formula:
C20H22F2N6
Formula Weight:
400.43
Specification
Targets&IC50:
PKBα: 0.5 nM; PKA: 450 nM
Relative Density:
1.353 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PF-AKT400 is used in drug development and signaling research as a potent and selective Akt inhibitor to investigate the pharmacodynamic effects of targeting the Akt pathway in vivo.
Library Information
Target:
Akt
Receptor:
Akt
Pathways:
Cytoskeletal signaling; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-22
Plate Location:
c5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
90 mg/mL; 224.76 mM
