Hu7691 free base

Cat. No.: OB0225WX-1637

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Hu7691 free base is a potent, orally active Akt inhibitor that targets all three isoforms (Akt1, 2, and 3) to induce cellular differentiation and arrest proliferation.

Synonym: Hu7691 (free base); 2241232-43-7; GTPL12722; Hu-7691; N-((3s,4s)-4-(3,4-difluorophenyl) piperidin-3-yl)-2-fluoro-4-(1-methyl-1h-pyrazol-5-yl)benzamide; N-[(3S,4S)-4-(3,4-difluorophenyl)piperidin-3-yl]-2-fluoro-4-(2-methylpyrazol-3-yl)benzamide

CAS No.: 2241232-43-7

Compound CID: 135274950

Formula: C₂₂H₂₁F₃N₄

Formula Weight: 414.423

Specification

Targets&IC50: Akt2: 97.5 nM (IC50); PKA: 11 nM; AKT1: 4.0 nM; mTOR (p70S6K): 229 nM; AKT3: 28 nM; RSK1: 756 nM (IC50); RSK1: 756 nM; AKT2: 97.5 nM; Akt1: 4.0 nM (IC50); Akt3: 28 nM (IC50); PKCη: 629 nM (IC50); PKCη: 629 nM; PKA: 11 nM (IC50); ROCK1: 354 nM; p70 S6K: 229 nM (IC50); ROCK1: 354 nM (IC50)

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Hu7691 free base is employed in medicinal chemistry research as a potent kinase inhibitor to study its pharmacodynamic profile and efficacy within the Akt signaling axis.