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PARP/PI3K-IN-1
Cat. No.:
OB0225WX-1520
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
PARP/PI3K-IN-1 is a dual-targeted molecule that simultaneously inhibits poly (ADP-ribose) polymerase (PARP) and PI3K, exhibiting potent antiproliferative and antitumour molecular characteristics.
Synonym:
2337386-47-5
CAS No.:
2337386-47-5
Formula:
C33H28F4N8O3
Formula Weight:
660.62
Specification
Targets&IC50:
PI3Kδ: 8.13 (pIC50); PI3Kβ: 6.54 (pIC50); PARP2: 8.44 (pIC50); PI3Kα: 8.25 (pIC50); PI3Kγ: 6.08 (pIC50); PARP1: 8.22 (pIC50)
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PARP/PI3K-IN-1 is utilized in synergistic therapy research to study the combined inhibitory effects on DNA repair and cell survival signaling pathways in various cancer models.
Library Information
Target:
PI3K; PARP
Receptor:
PI3K; PARP
Pathways:
DNA damage/DNA repair; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-20
Plate Location:
e5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
80 mg/mL; 121.10 mM
