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TAK-285
Cat. No.:
0225LY-0668
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
TAK-285 is a dual inhibitor of EGFR (HER1) and HER2 in Phase 1 trials (IC50: 23/17 nM) that maintains 10-fold selectivity over HER4 and is less effective against Lck, c-Met, and Aurora B.
Synonym:
TAK285; TAK 285; 871026-44-7; N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide; N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxy-3-methylbutanamide; 2-Benzamidoacetic acid, ((S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-1-ethoxy-1-oxopr
CAS No.:
871026-44-7
Compound CID:
11620908
Formula:
C26H25ClF3N5O3
Formula Weight:
547.96
Specification
Targets&IC50:
EGFR/HER1: 23 nM; HER2: 17 nM
Relative Density:
1.39 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
TAK-285 can be used in cancer research to evaluate its potent and dual inhibition of HER2 and EGFR.
Library Information
Target:
EGFR; HER; Aurora kinase; MEK
Receptor:
Aurora B; EGFR/HER1; HER2; HER4; MEK1
Pathways:
Tyrosine kinase/adaptors; Angiogenesis; Cell cycle/Checkpoint; JAK/STAT signaling; Chromatin/Epigenetic; MAPK
Plate Number:
AOCL-9
Plate Location:
f5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
102 mg/mL; 186.14 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
50 mg/mL; 91.25 mM
