Motesanib diphosphate (AMG-706)

Cat. No.: OB0225WX-2388

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Motesanib diphosphate is a potent, ATP-competitive inhibitor of VEGFR1, 2, and 3 (IC50: 2, 3, and 6 nM) with comparable activity against c-Kit and high selectivity over PDGFR.

Synonym: 857876-30-3; Motesanib diphosphate; AMG-706; Motesanib (Diphosphate); Motesanib Diphosphate (AMG-706); Motesanib phosphate; AMG 706 (Diphosphate); AMG706; 3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-((4-pyridinylmethyl)amino)-, phosphate (1:2); N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;phosphoric acid; MOTESANIB DIPHOSPHATE (MART.); N-(3,3-Dimethylindolin-6-yl)-2-((pyridin-4-ylmethyl)amino)nicotinamide diphosphate; N-(3,3-Dimethyl-2,3-dihydro-1H-indol-6-yl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide diphosphate; N-(3,3-Dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide diphosphate; MFCD12407403; N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide,phosphoric acid; N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide bis(phosphate); N-(3,3-Dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide diphosphate; N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide phosphate (1:2)

CAS No.: 857876-30-3

Compound CID: 16097729

Formula: C₂₂H₂₃N₅O·2H_3PO₄

Formula Weight: 569.44

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Motesanib diphosphate is used in oncological studies as a potent inhibitor of VEGF, PDGF, and Kit receptors to investigate the disruption of vascular development and the suppression of solid tumor xenografts.