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GSK5182
Cat. No.:
OB0225WX-2017
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
GSK5182 is a highly selective inverse agonist of the estrogen-related receptor gamma (ERR-gamma) featuring an IC50 value of 79 nM.
Synonym:
877387-37-6; (E/Z)-GSK5182; GSK 5182; (Z)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol; 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol; 4-[(Z)-1-[4-(2-dimethylaminoethoxy)phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol; 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol; 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol; 4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol; 4-[(z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-hydroxy-2-phenylpent-1-enyl]phenol
CAS No.:
877387-37-6
Compound CID:
6852176
Formula:
C27H31NO3
Formula Weight:
417.54
Specification
Targets&IC50:
ERRγ: 79 nM (IC50)
Relative Density:
1.132 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK5182 is used in metabolic and endocrine research as a selective inverse agonist of the estrogen-related receptor gamma (ERR-gamma) to study the regulation of hepatic glucose production.
Library Information
Target:
Estrogen/progestogen receptor; Estrogen receptor/ERR; Reactive oxygen species
Receptor:
ERRγ; Estrogen receptor/ERR; Reactive oxygen species
Pathways:
Endocrinology/Hormones; Metabolism; Immunology/Inflammation; NF-κB
Plate Number:
AOCL-26
Plate Location:
g10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 143.7 mM
