Glabridin

Cat. No.: 0225LY-0911

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, HPLC, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Glabridin regulates iNOS synthesis under high-glucose conditions to potentially treat diabetes-related vascular dysfunction; it also modulates glucose metabolism via AMPK in muscle cells and may act as a chemopreventive agent by hindering the invasion of human HCC cells.

Synonym: Q-100692; KB-289522; 59870-68-7; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol; 4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-1,3-benzenediol; MFCD03427694; 1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)-; 1,3-Benzenediol,4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl)-,(R)-; (R)-4-(8,8-dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol; (R)-Glabridin; (R)-4-(8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl)benzene-1,3-diol; 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol

CAS No.: 59870-68-7

Compound CID: 124052

Formula: C₂₀H₂₀O₄

Formula Weight: 324.37

Specification

Targets&IC50: α1β2 GABAA receptor: 9.63 μM(EC50); α1β1γ2 GABAA receptor: 17.23 μM(EC50); α1β3γ2 GABAA receptor: 6.83 μM(EC50); α1β2γ2 GABAA receptor: 6.3 μM(EC50)

Relative Density: 1.257 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Glabridin can be used in dermatological and metabolic studies to examine its role in skin lightening and glucose metabolism regulation.

Library Information

Target: PPAR; GABA receptor; Tyrosinase

Receptor: PPAR; T1 tyrosinase; T3 tyrosinase; α1β1γ2 GABAA receptor; α1β2 GABAA receptor; α1β2γ2 GABAA receptor; α1β3γ2 GABAA receptor

Pathways: Microbiology/Virology; Proteases/Proteasome; Membrane transporter/Ion channel; Neuronal signaling; NF-κB; DNA damage/DNA repair; Metabolism; Immunology/Inflammation

Plate Number: AOCL-12

Plate Location: g2

Empty Location: a1-h1; a12-h12

Container: 96-well plate

Formulation: 10mM DMSO

DMSO Max Solubility: 76 mg/mL; 234.3 mM

Solubility: Soluble in chloroform, dichloromethane, ethyl acetate, acetone, etc.

ALogP: 3.999

HBA_Count: 2

HBD_Count: 2

Rotatable Bond: 1