Product Overview
Description:
AdipoUpX™ Human ITGAX MSCV Particle (Overexpression) is a high-titer retroviral vector engineered for stable overexpression of the human ITGAX gene. ITGAX is a marker of pro-inflammatory immune cells and plays a role in adipose tissue inflammation in obesity. The MSCV system enables strong expression in hematopoietic stem cells, stem cells, and mammalian cell models. Each batch is tested for titer, sterility, and mycoplasma contamination.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
ITGB2
Full Name:
Integrin subunit beta 2
Gene Symbol:
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Summary:
ITGB2 produces the beta subunit of integrins, which pairs with various alpha subunits to form heterodimeric adhesion receptors on the cell surface. These receptors mediate cell–cell and cell–matrix interactions and are essential for immune cell trafficking and signaling. Loss-of-function variants disrupt leukocyte adhesion and lead to immunodeficiency syndromes. Several transcript isoforms arise through alternative splicing.
