AdipoUpX™ Human GHRL MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GHRL MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of human GHRL. The GHRL preproprotein is central to the gut-brain axis and appetite regulation pathway. Stable integration ensures reliable cell lines for neuroendocrinology research. This MMLV particle facilitates investigation of the cleavage products (ghrelin and obestatin) and their role in hunger signaling. Comprehensive quality control ensures the safety and efficacy of all viral products.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: GHRL

Full Name: Ghrelin and obestatin prepropeptide

Gene Symbol: MTLRP

Gene ID: 51738

RefSeq ID: NM_001134941.3, NP_001128413.1

Summary: The GHRL gene dictates the production of the precursor for the "hunger hormone," ghrelin. Secreted by the stomach when empty, ghrelin acts as the only known circulating appetite stimulant, binding to the growth hormone secretagogue receptor in the hypothalamus to trigger both feeding behavior and the release of growth hormone. This peptide is central to the gut-brain axis regulation of energy balance, gastric motility, and reward perception. While the associated peptide, obestatin, was initially thought to be a satiety signal, both peptides' roles in appetite and glucose metabolism remain under intense investigation for potential anti-obesity therapies.

AdipoUpX™ Human GHRL MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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