AdipoUpX™ Human ABCA1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ABCA1 MMLV Particle (Overexpression) is a high-titer, ready-to-use MMLV retroviral particle professionally engineered for the efficient and stable overexpression of the human ABCA1 gene. This transporter is a master regulator of cholesterol efflux and HDL biogenesis, making it a critical target for lipid metabolism research. Stable genomic integration ensures a reliable platform for researching reverse cholesterol transport in dividing host cells. Our viral system features a modular design, and all products are verified through comprehensive QC screening to guarantee the highest experimental standards.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: ABCA1

Full Name: ATP binding cassette subfamily A member 1

Gene Symbol: TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13

Gene ID: 19

RefSeq ID-1: NP_005493.2

RefSeq ID-2: NM_005502.3

Summary: ABCA1 encodes a membrane-associated ATP-binding cassette transporter that mediates cholesterol efflux. It belongs to the ABC1 subfamily, unique to multicellular eukaryotes. By transporting cholesterol out of cells, ABCA1 plays a critical role in lipid homeostasis. Mutations in both alleles cause Tangier disease and familial HDL deficiency.

AdipoUpX™ Human ABCA1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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