AdipoUpX™ Human TRIP12 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TRIP12 MMLV Particle (Overexpression) is a high-titer MMLV particle designed for the efficient and stable overexpression of the human TRIP12 gene. This E3 ubiquitin ligase is involved in the degradation of key metabolic regulators and has emerging roles in obesity-related signaling. The MMLV system’s ability to integrate into the host genome makes it a perfect tool for studying protein turnover in stable metabolic models. The viral system offers high flexibility for customization and is verified through comprehensive quality control.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: TRIP12

Full Name: Thyroid hormone receptor interactor 12

Gene Symbol: ULF; MRD49; TRIPC; TRIP-12

Gene ID: 9320

RefSeq ID-1: NP_001271143.1

RefSeq ID-2: NM_001284214.2

Summary: TRIP12 acts as a quality-control manager for the cell’s proteome. As an E3 ubiquitin ligase, it marks specific tumor suppressors (like p19ARF) and DNA-damage-response proteins for destruction. By regulating these levels, it ensures the cell responds correctly to genetic damage and prevents inappropriate cell cycle arrest.

AdipoUpX™ Human TRIP12 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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