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UPGL00004
Cat. No.:
OB0225WX-2778
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
UPGL00004 is a potent small molecule inhibitor of glutaminase C (GAC) with an IC50 of 29 nM, demonstrating high specificity for GAC over the GLS2 isoform.
Synonym:
1890169-95-5; 2-Phenyl-N-[5-[[1-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]piperidin-4-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide; 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide; 2-phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide; 2-Phenyl-N-[5-({1-[5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl]piperidin-4-yl}amino)-1,3,4-thiadiazol-2-yl]acetamide
CAS No.:
1890169-95-5
Compound CID:
121256411
Formula:
C25H26N8O2S2
Formula Weight:
534.66
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
UPGL00004 is used in metabolic oncology research as a potent and selective glutaminase (GLS1) inhibitor to investigate the disruption of glutamine metabolism and the inhibition of growth in various cancer cell lines.
Library Information
Target:
Glutaminase
Receptor:
Glutaminase
Pathways:
Proteases
Plate Number:
L6700-11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
25 mg/mL; 46.76 mM
ALogP:
3.091
HBA_Count:
6
HBD_Count:
3
Rotatable Bond:
9
