Saxagliptin (BMS-477118)

Cat. No.: OB0225WX-2423

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Saxagliptin (BMS-477118) is a high-affinity, reversible antagonist of the DPP4 enzyme, exhibiting a half-maximal inhibitory concentration (IC50) of 26 nM.

Synonym: Onglyza; BMS-477118; 361442-04-8; Saxagliptin; Onglyza; OPC-262; Saxagliptin anhydrous; (1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile; (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; (S)-3-Hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt; (1S,6S)-2-(2-adamantan-1-yl-2-amino-acetyl)-2-aza-bicyclo[3.1.0]hexane-3-carbonitrile; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2,2,2-trifluoroacetic acid; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; (1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1-yl)-acetyl]-2-aza-bicyclo[3.1.0]hexane-3-carbonitrile

CAS No.: 361442-04-8

Compound CID: 11243969

Formula: C₁₈H₂₅N₃O₂

Formula Weight: 315.41

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Saxagliptin (BMS-477118) is utilized in metabolic research as a potent and selective DPP-4 inhibitor to investigate the enhancement of incretin hormone levels and the improvement of glucose-dependent insulin secretion.