Nitidine chloride

Cat. No.: 0225LY-0703

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Nitidine chloride limits the growth of various malignancies, including breast and renal cancers; it inhibits SMMC-7721 cell proliferation in a dose- and time-dependent manner in vitro and has confirmed efficacy in mouse models of hepatocellular carcinoma (HCC).

Synonym: 13063-04-2; 2,3-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride; 2,3-Dimethoxy-12-methyl-(1,3)-benzodioxolo(5,6-c)phenanthridinium chloride; 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium

CAS No.: 13063-04-2

Compound CID: 25659

Formula: C₂₁H₁₈ClNO₄

Formula Weight: 383.82

Specification

Relative Density: 1.35 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Nitidine chloride can be used in cancer biology studies to explore its role as a potential inhibitor of DNA topoisomerase I and its impact on tumor cell survival.

Library Information

Target: NF-κB; p38 MAPK; ERK; FAK; Parasite protein; Topoisomerase; STAT

Receptor: ERK; FAK; NF-κB; p38 MAPK; Parasite protein; STAT; Topoisomerase

Pathways: DNA damage/DNA repair; Apoptosis; Stem cell regulation; JAK/STAT signaling; Tyrosine kinase/adaptors; Cytoskeletal signaling; Angiogenesis; NF-κB; MAPK; Microbiology/Virology

Plate Number: AOCL-10

Plate Location: a10

Empty Location: a1-h1; a12-h12

Container: 96-well plate

Formulation: 10mM DMSO

DMSO Max Solubility: 3.84 mg/mL; 10 mM

Solubility: Soluble in chloroform, dichloromethane, ethyl acetate, acetone, etc.