LY2874455

Cat. No.: OB0225WX-2664

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: LY2874455 is a pan-FGFR inhibitor with IC50 values ranging from 2.6 to 6.4 nM across the FGFR1-4 family, and it also exerts inhibitory effects on VEGFR2 with an IC50 of 7 nM.

Synonym: 1254473-64-7; LY-2874455; LY 2874455; 2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol; 1H-Pyrazole-1-ethanol, 4-((1E)-2-(5-((1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy)-1H-indazol-3-yl)ethenyl)-; (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethan-1-ol; (R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; 1H-Pyrazole-1-ethanol, 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-; (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol.; 2-(4-((E)-2-(5-((1R)-1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)ethenyl)-1H-pyrazol-1-yl)ethan-1-ol; 2-(4-((E)-2-(5-((1R)-1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)ethenyl)pyrazol-1-yl)ethanol; 2-{4-[(E)-2-{5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl}ethenyl]-1H-pyrazol-1-yl}ethan-1-ol; LY2874455 monohydrate

CAS No.: 1254473-64-7

Compound CID: 46944259

Formula: C₂₁H₁₉Cl₂N₅O₂

Formula Weight: 444.31

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: LY2874455 is applied in molecular biology as a potent pan-FGFR inhibitor to investigate the disruption of fibroblast growth factor-mediated signaling across all four receptor isoforms.