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Leniolisib
Cat. No.:
OB0225WX-1519
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
Leniolisib is a highly selective inhibitor of PI3Kδ, characterized by a potent IC50 value of 11 nM.
Synonym:
CDZ173; 1354690-24-6; Cdz173 free base; Cdz-173 free base; CDZ173-NX; Leniolisibum; CDZ-173-NX; CDZ173; Leniolisib free base; (S)-1-(3-((6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one; 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one; CDZ-173; 1-Propanone, 1-((3S)-3-((5,6,7,8-tetrahydro-6-(6-methoxy-5-(trifluoromethyl)-3-pyridinyl)pyrido(4,3-d)pyrimidin-4-yl)amino)-1-pyrrolidinyl)-
CAS No.:
1354690-24-6
Compound CID:
57495353
Formula:
C21H25F3N6O2
Formula Weight:
450.46
Specification
Targets&IC50:
PI3Kβ: 480 nM (cell free); PI3Kα: 280 nM (cell free); DNA-PK: 880 nM (cell free); PI3Kδ: 11 nM (cell free)
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Leniolisib is applied in immunological research specifically to investigate the treatment mechanisms for APDS (activated PI3K-delta syndrome) and related primary immunodeficiency disorders.
Library Information
Target:
DNA-PK; PI3K
Receptor:
DNA-PK; PI3Kδ
Pathways:
DNA damage/DNA repair; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-20
Plate Location:
e4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
16.67 mg/mL; 37 mM
Ethanol Max Solubility:
10 mg/mL
ALogP:
2.65
HBA_Count:
5
HBD_Count:
1
Rotatable Bond:
6
