Bay 11-7085

Cat. No.: OB0225WX-2682

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: BAY 11-7085 is an irreversible antagonist of TNF-alpha-induced I-kappa-B-alpha phosphorylation, characterized by a half-maximal inhibitory concentration (IC50) of 10 micromolar.

Synonym: bay 11-7085; 196309-76-9; (E)-3-((4-(tert-Butyl)phenyl)sulfonyl)acrylonitrile; (E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile; bay11-7085; BAY 11-7083; (E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile; MFCD01862602; BAY-117085; (E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile; BAY-11-7085; (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile; 3-((4-(1,1-dimethylethyl)phenyl)sulfonyl)-2-propenenitrile; BAY 11-7085; (E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile; BAY 117083; BAY 117085; 2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-; (E)-3-(4-tert-Butyl-benzenesulfonyl)-acrylonitrile; (E)-3-(4-tert-butylphenyl)sulfonyl-2-propenenitrile; (E)-3-(4-tert-butylphenylsulfonyl)-2-propenenitrile; (2E)-3-[(4-tert-butylphenyl)sulfonyl]prop-2-enenitrile; (2E)-3-(4-tert-butylbenzene-1-sulfonyl)prop-2-enenitrile

CAS No.: 196309-76-9

Compound CID: 5353432

Formula: C₁₃H₁₅NO₂S

Formula Weight: 249.33

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Bay 11-7085 is applied in molecular biology research to study the irreversible inhibition of IkappaB-alpha phosphorylation and its subsequent impact on preventing NF-kappaB-mediated pro-inflammatory gene expression.