AdipoUpX™ Human SIRT6 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human SIRT6 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human SIRT6 gene. Known for its role in DNA repair and glucose metabolism regulation, SIRT6 stable overexpression is a powerful tool for investigating the prevention of fatty liver and obesity-induced aging. All viral particle products undergo comprehensive quality control to ensure safety and efficacy. Our modular vector design offers high flexibility for customization, allowing researchers to select specific promoters for metabolic signaling studies.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: SIRT6

Full Name: Sirtuin 6

Gene Symbol: SIR2L6; hSIRT6

Gene ID: 51548

RefSeq ID-1: NP_001180214.1

RefSeq ID-2: NM_001193285.3

Summary: SIRT6 is a "genomic guardian" from the sirtuin family that uses NAD to regulate aging, DNA repair, and telomere stability. Located in the nucleus, it acts as a master regulator of energy homeostasis by fine-tuning lipid and glucose metabolism. Its ability to combat inflammation and maintain chromatin integrity makes it a primary target for research into longevity and metabolic resilience.

AdipoUpX™ Human SIRT6 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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