AdipoUpX™ Human SIRT1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human SIRT1 MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the long-lasting overexpression of the human SIRT1 gene. This deacetylase is a master regulator of metabolic health, longevity, and mitochondrial biogenesis. Due to its stable integration into dividing cell genomes, this MMLV particle is perfect for accelerating the establishment of stable cell lines to study the prevention of metabolic syndrome. Comprehensive quality control ensures the safety and efficacy of all viral products.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: SIRT1

Full Name: Sirtuin 1

Gene Symbol: SIR2; SIR2L1; SIR2alpha

Gene ID: 23411

RefSeq ID-1: NP_001135970.1

RefSeq ID-2: NM_001142498.1

Summary: The SIRT1 gene produces a member of the class I sirtuin family, serving as a human homolog to the yeast Sir2 protein. As an NAD-dependent deacetylase and mono-ADP-ribosyltransferase, SIRT1 acts as an intracellular metabolic sensor. It is involved in various regulatory processes, including epigenetic gene silencing and the cellular response to caloric restriction, making it a critical factor in metabolic adaptation and longevity.

AdipoUpX™ Human SIRT1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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