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AdipoUpX™ Human APOB MMLV Particle (Overexpression)

Cat. No.: V1225XX639
Species: Human
Target Gene: APOB
Vector System: MMLV Retrovirus
Modulation Type: Overexpression
AdipoUpX™ Human APOB MMLV Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human APOB MMLV Particle (Overexpression) is a high-titer MMLV particle designed for the efficient and stable overexpression of the human APOB gene. As the primary apolipoprotein of low-density lipoproteins, it is a critical tool for studying atherogenesis and lipid transport in metabolic disease. The MMLV system features a modular design, offering high flexibility for customization. Comprehensive quality control is performed on every batch to ensure product efficacy and the highest standards of safety for lipid research.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.
Sterility Test: The final viral preparation was confirmed sterile after testing.
Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.
Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.
Storage: The product must be immediately transferred to -80 °C storage upon its arrival.
Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.
Shipping Condition: Our MMLV retroviral products are shipped using dry ice.
Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: APOB
Full Name: Apolipoprotein B
Gene Symbol: FLDB; FCHL2; LDLCQ4; apoB-48; apoB-100
Gene ID: 338
RefSeq ID-1: NP_000375.3
RefSeq ID-2: NM_000384.3
Summary: APOB is a single, massive gene that produces the main apolipoprotein found in chylomicrons and low-density lipoproteins (LDL). It serves as the exclusive ligand for the LDL receptor, mediating the clearance of cholesterol-rich particles from the plasma. This gene achieves its output through a unique post-transcriptional process called RNA editing. Editing the primary transcript in the gut results in the shorter ApoB-48 isoform, while the full-length transcript is translated in the liver to ApoB-100. Mutations or defects in the APOB gene or its regulatory region cause several lipid disorders, including hypobetalipoproteinemia and hypercholesterolemia due to ligand-defective ApoB.

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