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AdipoUpX™ Human TNF MMLV Particle (Overexpression)

Cat. No.: V1225XX629
Species: Human
Target Gene: TNF
Vector System: MMLV Retrovirus
Modulation Type: Overexpression
AdipoUpX™ Human TNF MMLV Particle (Overexpression)
INQUIRY Datasheet MSDS
SPECIFIC INQUIRY
Mammalian Cell Selection:
Fluorescent Reporters:
Titer:
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Product Overview

Description: AdipoUpX™ Human TNF MMLV Particle (Overexpression) is a high-titer MMLV particle designed for the efficient and stable overexpression of the human TNF (TNF-alpha) gene. As a master pro-inflammatory cytokine, it is a primary tool for researching the inflammatory link between obesity and Type 2 Diabetes. The MMLV system's stable integration into dividing cells makes it ideal for investigating the chronic effects of inflammation in stable cell lines. The viral system offers high flexibility for customization and is verified by comprehensive quality control.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.
Sterility Test: The final viral preparation was confirmed sterile after testing.
Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.
Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.
Storage: The product must be immediately transferred to -80 °C storage upon its arrival.
Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.
Shipping Condition: Our MMLV retroviral products are shipped using dry ice.
Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: TNF
Full Name: Tumor necrosis factor
Gene Symbol: DIF; TNFA; IMD127; TNFSF2; TNLG1F; TNF-alpha
Gene ID: 7124
RefSeq ID-1: NP_000585.2
RefSeq ID-2: NM_000594.3
Summary: TNF encodes a potent, multifunctional proinflammatory cytokine primarily secreted by macrophages, belonging to the TNF superfamily. TNF mediates its effects by binding to its receptors (TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR). It is a fundamental regulator of diverse biological processes, including cell proliferation, apoptosis, coagulation, and lipid metabolism. Dysregulated TNF signaling is central to the pathogenesis of numerous conditions, including autoimmune diseases (rheumatoid arthritis), insulin resistance, psoriasis, and various cancers. TNF also plays a protective role, suggested by mouse knockout studies, but mutations affect susceptibility to severe infections and Alzheimer's disease.

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