AdipoUpX™ Human SDCCAG8 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human SDCCAG8 MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human SDCCAG8 gene. Associated with Bardet-Biedl Syndrome and renal-metabolic dysfunction, its stable integration into dividing cell genomes is essential for investigating centrosomal and ciliary signaling. This product facilitates the rapid validation of its role in establishing energy balance. All viral products undergo comprehensive quality control to ensure safety, and customization of promoters and markers is highly flexible to suit diverse research needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: SDCCAG8

Full Name: SHH signaling and ciliogenesis regulator SDCCAG8

Gene Symbol: BBS16; CCCAP; SLSN7; NPHP10; hCCCAP; HSPC085; NY-CO-8; CCCAP SLSN7

Gene ID: 10806

RefSeq ID-1: NP_006633.1

RefSeq ID-2: NM_006642.5

Summary: SDCCAG8 encodes a protein localized to the centrosome and the basal body of cilia. It is essential for organizing the cellular scaffold during interphase and mitosis. Because of its location, it is critical for the structural integrity of the primary cilium. Mutations in this gene lead to retinal-renal ciliopathy, a condition that links ciliary dysfunction to kidney failure and vision loss, underscoring its role in the coordination of cellular development.

AdipoUpX™ Human SDCCAG8 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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