AdipoUpX™ Human RAB23 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human RAB23 Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human RAB23 gene. As a negative regulator of Hedgehog signaling, it is a critical tool for studying ciliary function and its link to syndromic obesity. All viral particle products undergo comprehensive quality control to ensure safety and efficacy. Our customizable platform allows researchers to flexibly select reporter genes and cell-specific promoters for precise targeted delivery and high-resolution tracking.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: RAB23

Full Name: RAB23, member RAS oncogene family

Gene Symbol: HSPC137

Gene ID: 51715

RefSeq ID-1: NP_001265595.1

RefSeq ID-2: NM_001278666.2

Summary: RAB23 is a small GTPase within the Ras superfamily that regulates intracellular membrane trafficking, including pathways for autophagy and immune defense. It plays a critical role in brain development by inhibiting the Sonic Hedgehog signaling pathway. Mutations in RAB23 result in Carpenter syndrome, a condition that encompasses physical malformations and metabolic complications.

AdipoUpX™ Human RAB23 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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