LipoKnoxa™ Human ADRB2 shRNA Lentiviral Particle (Silencing)

Cat. No.: V0126XX452

Species: Human

Target Gene: ADRB2

Vector System: Lentiviral

Modulation Type: Silencing (shRNA)

LipoKnoxa™ Human ADRB2 shRNA Lentiviral Particle (Silencing)

INQUIRY Datasheet MSDS

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX452-1	GGACCTGAGTCTGCTATATTT	3' UTR	Inquiry
V0126XX452-2	GAACACTAAACAGACTATTTA	3' UTR	Inquiry
V0126XX452-3	AGGTACTGTGCCTAGCGATAA	CDS	Inquiry
V0126XX452-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human ADRB2 shRNA Lentiviral Particle (Silencing) targets the ADRB2 to facilitate the study of catecholamine-regulated lipolysis and thermogenesis. This lentiviral system supports both U6 and miR30-based shRNA systems, offering flexible options for silencing depth and cell-type specificity. To ensure optimal experimental reliability, each preparation is verified via rigorous quality control covering sequence integrity and microbial contaminants, supporting stable gene integration in both primary cells and established cell lines.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: ADRB2

Full Name: Adrenoceptor beta 2

Gene Symbol: BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR

Gene ID: 154

RefSeq ID-1: NP_000015.2

RefSeq ID-2: NM_000024.6

Summary: This gene encodes the beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily. The receptor forms a signaling complex with its effector, the class C L-type calcium channel Ca(V)1.2, along with a G protein, adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase PP2A. This assembly allows precise and rapid signaling. ADRB2 also acts as a transcription regulator for the alpha-synuclein gene, with both genes linked to Parkinson’s disease risk. Being intronless, this gene has multiple polymorphic forms and mutations, which have been associated with nocturnal asthma, obesity, type 2 diabetes, and cardiovascular disease.

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