AdipoUpX™ Human TCF7L2 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TCF7L2 Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human TCF7L2 gene. As one of the most significant genetic risk factors for diabetes, its stable expression in cell models allows for systematic investigation into Wnt signaling and beta-cell survival. The product is ready-to-use and high-titer, with every lot passing rigorous quality control for titer and sterility. Our modular design provides high flexibility for customization of functional markers.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: TCF7L2

Full Name: Transcription factor 7 like 2

Gene Symbol: TCF4; TCF-4

Gene ID: 6934

RefSeq ID-1: NP_001139746.1

RefSeq ID-2: NM_001146274.2

Summary: TCF7L2 encodes a transcription factor containing a high mobility group (HMG) box and functions as a critical regulator of the Wnt signaling pathway. It has a significant role in glucose homeostasis, and variants of this gene are associated with increased susceptibility to type 2 diabetes. Multiple transcript variants encoding distinct isoforms have been identified.

AdipoUpX™ Human TCF7L2 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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