AdipoUpX™ Human BBS12 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human BBS12 Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human BBS12 gene. This chaperonin-like protein is a key target for investigating adipocyte differentiation and its defects in Bardet-Biedl syndrome. Every batch is verified through comprehensive quality control screening (titer, sterility, and mycoplasma), ensuring that experimental results are both repeatable and safe. Our platform allows for flexible customization of functional markers for precise targeted delivery and tracking.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: BBS12

Full Name: Bardet-Biedl syndrome 12

Gene Symbol: C4orf24

Gene ID: 166379

RefSeq ID-1: NP_001171478.1

RefSeq ID-2: NM_001178007.2

Summary: BBS12 encodes a chaperonin-like protein that participates in protein folding and intracellular membrane trafficking. It is essential for the assembly of the BBSome complex and contributes to adipocyte differentiation. Defective BBS12 function causes Bardet–Biedl syndrome type 12, a ciliopathy associated with obesity, retinal degeneration, and other clinical features. Two transcript variants encoding the same protein have been described.

AdipoUpX™ Human BBS12 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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