AdipoUpX™ Human GFRAL Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GFRAL Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the long-lasting overexpression of the human GFRAL gene. As the specific receptor for GDF15, its stable integration is essential for studying the hindbrain-mediated suppression of appetite and weight loss. All viral particle products undergo comprehensive quality control to ensure safety and efficacy. Our modular vector design offers high flexibility for customization, allowing for precise targeted delivery in neuroendocrine research.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: GFRAL

Full Name: GDNF family receptor alpha like

Gene Symbol: GRAL; UNQ9356; C6orf144; bA360D14.1

Gene ID: 389400

RefSeq ID-1: NP_997293.2

RefSeq ID-2: NM_207410.2

Summary: GFRAL is a highly specialized receptor found in the hindbrain that serves as the exclusive landing site for the hormone GDF15. When GDF15 binds to GFRAL, it triggers a signaling cascade that potently suppresses appetite and induces weight loss. This makes GFRAL a cornerstone of the body’s "emergency" system for reducing food intake during stress or illness.

AdipoUpX™ Human GFRAL Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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