AdipoUpX™ Human TRIP12 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TRIP12 Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human TRIP12 gene. As an E3 ubiquitin-protein ligase, it is an essential tool for investigating the targeted degradation of proteins involved in energy sensing and obesity pathways. Every batch is verified through comprehensive quality control screening (titer, sterility, and mycoplasma), ensuring that results are repeatable. The lentivirus characteristic of genome integration establishes permanent cell models for longitudinal functional studies.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: TRIP12

Full Name: Thyroid hormone receptor interactor 12

Gene Symbol: ULF; MRD49; TRIPC; TRIP-12

Gene ID: 9320

RefSeq ID-1: NP_001271143.1

RefSeq ID-2: NM_001284214.2

Summary: TRIP12 encodes an E3 ubiquitin ligase that targets the tumor suppressor p19ARF for degradation and regulates DNA damage responses by controlling USP7 stability and p53 signaling. Although primarily studied in cancer biology, ubiquitin-mediated protein turnover regulated by TRIP12 may influence adipocyte differentiation and metabolic stress responses, processes relevant to obesity and energy balance.

AdipoUpX™ Human TRIP12 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

Related Products