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AdipoUpX™ Human ENPP1 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX401
Species: Human
Target Gene: ENPP1
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human ENPP1 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human ENPP1 Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle professionally engineered for the long-lasting, stable overexpression of the human ENPP1 gene. Integrating into the host genome, it allows for the establishment of reliable cell lines to study ENPP1 as a key inhibitor of insulin receptor signaling. Every batch undergoes rigorous quality control, including titer, sterility, and mycoplasma testing, ensuring experimental reproducibility. Our modular vector system offers high flexibility, allowing clients to customize promoters and markers for precise metabolic research.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ENPP1
Full Name: Ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene Symbol: M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1
Gene ID: 5167
RefSeq ID-1: NP_006199.2
RefSeq ID-2: NM_006208.3
Summary: ENPP1 belongs to a family of ecto-nucleotide enzymes that function as a dimeric transmembrane glycoprotein. This protein exhibits broad hydrolytic activity, cleaving phosphodiester and pyrophosphate bonds in various nucleotides and nucleotide sugars. It effectively dismantles compounds like nucleoside 5' triphosphates into monophosphates. Functionally, ENPP1 is a key player in regulating extracellular signaling and is highly significant in disease: genetic variants are strongly linked to insulin resistance, idiopathic infantile arterial calcification, and the spinal condition ossification of the posterior longitudinal ligament (OPLL).

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