AdipoUpX™ Human MC4R MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human MC4R MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of human MC4R. The MC4R receptor is central to the hypothalamic appetite regulation pathway. Stable integration ensures reliable cell lines for drug screening and neuroendocrinology research. This MMLV particle facilitates investigation of MC4R's downstream signaling mechanisms and its role in energy balance. Comprehensive quality control ensures the safety and efficacy of all viral products.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: MC4R

Full Name: Melanocortin receptor 4

Gene Symbol: BMIQ20

Gene ID: 4160

RefSeq ID: NM_005912.3, NP_005903.2

Summary: The protein encoded by the MC4R gene is a membrane receptor playing a critical role in the neuroendocrine system. Belonging to the melanocortin receptor family, it functions as a G protein-coupled receptor that directly regulates feeding behavior in the central nervous system by mediating interactions with adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH). The MC4R gene lacks introns and possesses a relatively simple structure, yet its functional defects represent the most common cause of monogenic autosomal dominant obesity in humans.

AdipoUpX™ Human MC4R MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

Related Products